Publications by Dr. Aszterbaum

The following publications were authored or co-authored by Dr. Aszterbaum in peer-reviewed journals and/or book chapters:

Aszterbaum, M., Feingold, K.R., Menon, G.K., Williams, M.L.  Ontogeny of the epidermal barrier to water loss in the rat:  Correlation of function with stratum corneum structure and lipid content.  Pediatric Research 31:308-317, 1992.               

Aszterbaum, M., Feingold, K.R., Menon, G.K., Williams, M.L. Glucocorticoids accelerate maturation of the epidermal permeability barrier in the rat.  Journal of Clinical Investigation 91:2703-2708, 1993.

Aszterbaum, M, Rothman, A, Johnson, R.L., Fisher, M, Xie, JW, Bonifas, J.M., Zhang, X., Scott, M.P., Epstein, E.H., Jr.  Mutations in the human PATCHED  gene in sporadic basal cell carcinomas and in patients with basal cell nevus sydrome.  J Invest Dermatol 110: 885-888, 1998.

Aszterbaum, M, Beech J, Epstein EH Jr.  Ultraviolet radiation mutagenesis of hedgehog pathway genes and basal cell carcinoma tumorigenesis. J Invest Dermatol, 4: 101-104, 1999

Aszterbaum, M, Epstein, J, Oro, T., Scott, M., Epstein, E.  A mouse model of human basal cell carcinoma: ultraviolet and gamma radiation enhance basal cell carcinoma growth in PATCHED heterozygote knock-out mice. Nature Medicine, 5(11): 1285-1291, 1999.

Tang JY, Aszterbaum M, Athar M, Barsanti F, Cappola C, Estevez N, Hebert J, Hwang J, Khaimskiy Y, Kim A, Lu Y, So PL, Tang X, Kohn MA, McCulloch CE, Kopelovich L, Bickers DR, Epstein EH Jr. Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice. Cancer Prev Res  Jan;3(1):25-34, 2010.

Tang JY, Mackay-Wiggan JM, Aszterbaum  M, Yauch RL, Lindgren J, Chang K, Coppola C, Canana AM, Marji J, Bickers DR, Epstein EH Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome.  New Eng J Med. 2012 Jun 7;366(23):2180-8.                                                             

Tang JY, Wu A, Linos E, Parimi N, Lee W, Aszterbaum M, Asgari MM, Bickers DR, Epstein EH Jr. High prevalence of vitamin D deficiency in patients with basal cell nevus syndrome.  Arch Dermatol. Oct;146(10):1105-10, 2010.

Xie, J, Aszterbaum, M, Bonifas, J, Zhang, X, Epstein, E., McCormick, F.  The role of the Gli1 target gene PDGF receptor alpha in driving basal cell carcinoma proliferation. Proceedings of the National Academy of Sciences, 98 (16): 9255-9, 2001.

Williams, M.L., Aszterbaum, M., Feingold, K.R., Menon, G.K., Hoath, S.B. Preservation of permeability barrier ontogenesis in the growth-retarded fetal rat.  Pediatric Research 33:415-424, 1993. (co-author and co-investigator)

Athar M, An KP, Morel kd, Kim AL, Aszterbaum M, Longley J, Epstein EH Jr, Bickers DR.  Ultraviolet B (UVB)-induced cox-2 expression in murine skin: an immunohistochemical study.  Biochem Biophys Res Commun.  280 (4): 1042-7, 2001.

Hebert JL, Khygyani F, Athar M, Kopelovich L, Epstein EH Jr, Aszterbaum M.  Chemoprevention of basal cell carcinomas in the ptc1+/- mouse—green and black tea.  Skin Pharmacol Appl Skin Physiol.  14(6): 358-62, 2001.

Dellavalle RP, Walsh P, Marchbank A, Grayson TE, Su LJ, Parker ER, DeGregori J, Penheiter K, Aszterbaum M, Epstein EH Jr, Lee LA.  CUSP/p63 expression in basal cell carcinoma Exp Dermatol 11(3):203-8, 2002.

An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, Aszterbaum M, Kopelovich L, Epstein EH Jr, Mukhtar H, Bickers DR Cyclooxygenase-2 expression in murine and human nonmelaanoma skin cacer implications for therapeutic approaches. Photochem Photobiol. 76(1): 73-80, 2002.

Hu Z, Bonifas JM, Aragon G, Kopelovich L, Liang Y, Ohta S, Israel MA, Bickers DR, Aszterbaum M, Epstein EH Jr.  Evidence of lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Res 63(5): 923-8, 2003.

Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein EH Jr, Bickers DR, Athar M.  Ornithinge decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest. 113(6):867-75, 2004.

So PL, Lee K, Hebert J, Walker P, Lu Y, Hwang J, Kopelovich L, Athar M, Bickers D, Aszterbaum M, Epstein EH Jr.  Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch 1+/- mice exposed to ultraviolet or ionizing radiation.  Cancer Res. 64(13): 4385-9, 2004.

So PL, Langston AW, Daniallinia N, Hebert JL, Fujimoto MA, Khaimskiy Y, Aszterbaum M, Epstein EH Jr. Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors.  Exp Dermatol. 15(9): 742-50, 2006.
BOOK REVIEW: Epstein, E.H. Jr., Aszterbaum, M. Genetic Skin Disorders. New Engand Journal of Medicine. 338:479, 1998.

Michelle Aszterbaum, M.D.

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